主持及主要參與課題：
1.國家自然科學(xué)基金:AKT活化的腫瘤細(xì)胞中HIF-1清除ROS的分子機(jī)制研究,；2010.1-2012.12(NO.30900596);主持人
2.國家自然科學(xué)基金：乏氧微環(huán)境下FOXP3在胰腺癌細(xì)胞中的表達(dá)調(diào)控機(jī)制及其功能研究；2013.1-2016.12(NO.81272685)主持人
3.國家自然科學(xué)基金： HIF基因3’UTR區(qū)SNP參與胰腺癌HIF-1a表達(dá)調(diào)控的分子機(jī)制及功能研究,；2014.1-2016.12(NO.81302082)第一參加人
4.國家自然科學(xué)基金:肝癌細(xì)胞乏氧微環(huán)境下kit配基的表達(dá)調(diào)控機(jī)制及功能研究: 2010.1-2012.12(NO.30901448)第一參加人
5.中國博士后科學(xué)基金:“HIF-1與CX3CR1/CX3CL1信號作用介導(dǎo)的胰腺癌嗜神經(jīng)浸潤研究”,，2009.01-2010.12(No.20090450773)主持人
主要發(fā)表論文：
1.Feng Li(#), Xiao Zhao(#), Hai Wang, Ruifang Zhao, TianjiaoJi, He Ren, Gregory J. Anderson, GuangjunNie* and JihuiHao*. Multiple Layer-by-Layer Lipid-Polymer Hybrid Nanoparticles for Improved FOLFIRINOX Chemotherapy in Pancreatic Tumor Models. Advanced Functional Materials.2015;25(5):788-798. (IF: 11.805)
2.Zhao T(#), Ren H(#), Li J(#), Chen J, Zhang H, Xin W, Sun Y, Sun L, Yang Y, Sun J, Wang X, Gao S, Huang C, Zhang H, Yang S, Hao J*. LASP1 is a HIF-1α target gene critical for metastasis of pancreatic cancer.Cancer Res.2015;75(1):111-119. (IF: 9.329)
3.Zhao X (#), Li F (#), Li YY (#), Wang H, Ren H, Chen J, Nie GJ*,Hao JH*. Co-delivery of HIF1 siRNA and Gemcitabine via Biocompatible Lipid-polymer Hybrid Nanoparticles for Effective Treatment of Pancreatic Cancer. Biomaterials. 2015;46:13-25. (IF: 8.557)
4.Tiansuo Zhao (#), He Ren (#), Li Jia, Jing Chen, Wen Xin, Fan Yan, Jing Li, Xiuchao Wang, Song Gao, Dong Qian, Chongbiao Huang,JihuiHao*. Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma. Oncotarget. 2015;6(4):2250-2262.(IF: 6.359)
5.Xiao Zhao (#), Song Gao (#), He Ren, Wei Sun, Huan Zhang, Jianwei Sun, Shengyu Yang, JihuiHao*. HIF-1 promotes pancreatic ductal adenocarcinoma invasion and metastasis by activating transcription of the actin-bundling protein fascin. Cancer Res. 2014;74(9):2455-2464. (IF: 9.329)
6.Wang X (#), Ren H (#), Zhao T, Chen J, Sun W, Sun Y, Ma W, Wang J, Gao C, Gao S, Lang M, Jia L*, Hao J*. Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection.Carcinogenesis. 2014 Oct;35(10):2283-2290. (IF: 5.334)
7.Ren H (#), Jia L (#), Zhao T, Zhang H, Chen J, Yang S, Liu J, Yu M, Hao J*.Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells.Cancer Lett. 2014;354(1):172-180. (IF: 5.621)
8.Zhao X(#), Gao S, Ren H, Huang H, Ji W, Hao J*.Inhibition of Autophagy Strengthens Celastrol-Induced Apoptosis in Human Pancreatic Cancer in Vitro and in Vivo Models. CurrMol Med. 2014;14(4):555-563. (IF: 3.621)
9.Zhang H(#), Chen J(#), Liu F(#), Gao C, Wang X, Zhao T, Liu J, Gao S, Zhao X, Ren H*,HaoJ*.CypA, a Gene Downstream of HIF-1α, Promotes the Development of PDAC. PLoS One. 2014;9(3):e92824. (IF: 3.234)
10.Chunhua Ren(#), Chao Xu(#), Dongxia Li, He Ren, Jihui Hao*, Zhimou Yang*. Gemcitabine induced supramolecular hydrogelations of aldehyde-containing short peptides. RSC Adv. 2014;4:34729-34732. (IF: 3.84)
11.Peng Jin(#), XiaoyanJi, He Ren, Yong Tang,JihuiHao*. Resection or cryosurgery relates with pancreatic tumor type: primary pancreatic cancer with previous non-pancreatic cancer or secondary metastatic cancer within the pancreas. Pancreatology. 2014;14(1):64-70. (IF:2.837)
12.Jin P(#), Ren H, Sun W, Xin W, Zhang H, Hao J*. Circulating IL-35 in pancreatic ductal adenocarcinoma patients. Hum Immunol. 2014;75(1):29-33.(IF: 2.138)
13.Ren H(#), Zhang H(#), Wang X, Liu J, Yuan Z, Hao J*. Prostate-specific membrane antigen as a marker of pancreatic cancer cells. Med Oncol. 2014;31(3):857. (IF: 2.634)
14.JunweiSun(#), Pingping Zhang, He Ren,JihuiHao*. Pancreaticoduo-denectomy and pancreaticoduo-denectomy combined with superior mesenteric-portal vein resection for elderly cancer patients. Hepatobiliary & Pancreatic Diseases International. 2014;13(4):428-434.(IF: 1.517)
15.Sun W(#), Ren H, Gao CT, Ma WD, Luo L, Liu Y, Jin P, Hao JH*. Clinical and Prognostic Significance of Coagulation Assays in Pancreatic Cancer Patients With Absence of Venous Thromboembolism. Am J ClinOncol. 2014 Jan 7. (IF: 3.062)
16.Ren H(#), Zhao T(#), Sun J(#), Wang X, Liu J, Gao S, Yu M, Hao J*. The CX3CL1/CX3CR1 reprograms glucose metabolism through HIF-1 pathway in pancreatic adenocarcinoma. J Cell Biochem. 2013;114(11):2603-2611. (IF: 3.368)
17.Zhao T(#), Gao S(#), Wang X, Liu J, Duan Y, Yuan Z, Sheng J, Li S, Wang F, Yu M, Ren H*,Hao J*.Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene. PLoS One. 2012;7(8):e43399. (IF: 3.73)
18.Liu F(#), Tang Y(#), Sun J, Yuan Z, Li S, Sheng J, Ren H, Hao J*. Regional intra-arterial vs. systemic chemotherapy for advanced pancreatic cancer: a systematic review and meta-analysis of randomized controlled trials. PLoS One. 2012;7(7):e40847.(IF: 3.73)
19.Wang X(#), Liu Y(#), Ren H, Yuan Z, Li S, Sheng J, Zhao T, Chen Y, Liu F, Wang F, Huang H*, Hao J*. Polymorphisms in the hypoxia-inducible factor-1a gene confer susceptibility to pancreatic cancer. Cancer BiolTher. 2011;12(5):383-387. (IF:2.636)
20.Liu M (#), Wang X (#), Yang Y, Li D, Ren H, Zhu Q, Chen Q, Han S, Hao J*,Zhou J*. Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumourigenesis. J Pathol. 2010 Jun;221(2):221-228. (IF:7.429)
21.Ren H(#)*, Zhao T(#), Wang X, Gao C, Wang J, Yu M, Hao J*.Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells. BiochemBiophys Res Commun. 2010;394(1):59-63. (IF:2.297)
22.Wang D, Chen K, Du WT, Han ZB, Ren H, Chi Y, Yang SG, Bayard F, Zhu D, Han ZC. CD14+ monocytes promote the immunosuppressive effect of human umbilical cord matrix stem cells. Exp Cell Res. 2010,316(15):2414-2423. (IF=3.557)
23.Chen K, Wang D, Du WT, Han ZB, Ren H, Chi Y, Yang SG, Zhu D, Bayard F, Han ZC. Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism. ClinImmunol. 2010,135(3):448-458. (IF=3.771)
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