国产天美传媒性色av|大象传媒一区|爱豆传媒mad004|麻豆传媒md系列视频在线观看|91制片厂果冻传媒资料|51黑料吃瓜每日精品|91制片厂官网怎么找人|91麻豆传媒找个按摩师|麻豆传媒映画映视频王茜|人人操日日操,日本www视频,麻豆映画传媒md0051国风旗袍,欧美精品精品在线

　　張寧,，博士,，教授,，PI,，博士生導(dǎo)師。國家杰出青年科學(xué)基金獲得者,，973首席科學(xué)家,。2001年畢業(yè)于約翰.霍普金斯大學(xué)醫(yī)學(xué)院，獲生化,、細胞及分子生物學(xué)博士學(xué)位�,，F(xiàn)任天津醫(yī)科大學(xué)副校長,，天津市基礎(chǔ)醫(yī)學(xué)研究中心主任,，天津醫(yī)科大學(xué)附屬腫瘤醫(yī)院研究所中心實驗室PI，中國抗癌協(xié)會副秘書長,，天津市細胞學(xué)會副理事長,，天津市生物醫(yī)學(xué)工程學(xué)會副理事長。

　　長期從事生物醫(yī)學(xué)及細胞生物學(xué)研究，圍繞癌轉(zhuǎn)移這一關(guān)鍵臨床難題,，從機理研究,、生物標志物鑒定、藥物篩選,、納米技術(shù)等多個側(cè)面入手展開轉(zhuǎn)化應(yīng)用研究,，取得了一系列科研成果。初步揭示了一個調(diào)控癌細胞趨化運動的信號傳導(dǎo)通路,。建立了一個新的藥物篩選細胞模型,，篩選獲得兩個先導(dǎo)化合物，一個抗癌轉(zhuǎn)移化合物,，已申請專利并開展臨床前研究工作,。近年來開始將研究領(lǐng)域拓展至納米腫瘤學(xué)領(lǐng)域，致力于納米技術(shù)在腫瘤診療中的應(yīng)用研究,。近五年在Cancer Research,、ACS Nano、Journal of Clinical Investigation等國際期刊中發(fā)表SCI文章35篇,，總IF為159.816,，其中24篇為通訊作者或共同通訊作者；申請國家級專利7項,，其中1項已授權(quán),；作為項目負責人，承擔了國家973重大科學(xué)研究計劃納米領(lǐng)域項目1項,、國家杰出青年科學(xué)基金1相,、863課題1項、國家自然基金3項,、科技部攻關(guān)子項目1項,、省部級課題4項。張寧教授的工作得到國內(nèi)外同行的認可,，因此先后成為國家杰出青年基金獲得者,，獲得天津市青年科技獎，被評為天津市十佳杰出留學(xué)人員,，獲得教育部新世紀優(yōu)秀人才稱號等,。

　　代表性論文

    1、De Yang, Yuliang Zhao, Hua Guo, Yana Li, Poonam Tewary, Gengmei Xing, Wei Hou, Joost J. Oppenheim, and Ning Zhang*. [Gd@C(82)(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses. ACS Nano. 2010 Feb 23;4(2):1178-86.(通訊作者) IF=11.421

    2,、Fei Zhang, Xiaofang Zhang, Menghui Li, Peng Chen, Bin Zhang, Hua Guo, Wenfeng Cao, Xiying Wei, Xuchen Cao, Xishan Hao, Ning Zhang*. mTOR Complex Component Rictor Interacts with PKC{zeta} and Regulates Cancer Cell Metastasis. Cancer Research. 2010 Nov 15; 70(22):9360-70. (通訊作者)IF=7.856

    3,、Ying Qu, Jinhua Wang, Partha S. Ray, Hua Guo, Jian Huang, Miyung Shin-Sim, Bolanle A. Bukoye, Bingya Liu, Adrian V. Lee, Xin Lin, Peng Huang, John W. Martens, Armando E. Giuliano, Ning Zhang*, Ning-Hui Cheng*, Xiaojiang Cui*. Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling. Journal of Clinical Investigation. 2011 Jan 4;121(1):212-25 (共同通訊作者) IF=13.069

    4、Jiajia Hu, Hua Guo, Hongyan Li, Yan Liu, Jingjing Liu, Liwei Chen, Jin Zhang, Ning Zhang. MiR-145 Regulates Epithelial to Mesenchymal Transition of Breast Cancer Cells by Targeting Oct4. PLoS One. 2012;7(9):e4596 (通訊作者) IF=4.092

    5,、Fei Zhang, Lin Zhang, Bin Zhang, Xiyin Wei, Yi Yang, Robert Zhong Qi, Guoguang Ying, Ning Zhang* , Ruifang Niu*. Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cells. Journal of Proteome Research. 2009 Nov;8(11):5041-7.(共同通訊作者)IF=5.113

    6,、Baogang Zhang, Yongjie Ma,Hua Guo, Baocun Sun, Ruifang Niu, Guoguang Ying, and Ning Zhang*. Akt2 Is Required for Macrophage Chemotaxis. European Journal of Immunology 2009 Mar;39(3):894-901 (通訊作者) IF=5.103

    7、Hua Guo, Yongjie Ma, Baogang Zhang, Baocun Sun, Ruifang Niu, Guoguang Ying, and Ning Zhang*. Pivotal Advance: PKC zeta is required for migration of macrophages. Journal of Leukocyte Biology 2009 Jun;85(6):911-8.(通訊作者) IF=4.992

    8、Ying Liu, Jingna Wang, Min Wu, Wuzhou Wan, Ronghua Sun, De Yang, Xiangjun Sun, Dalong Ma, Guoguang Ying*, Ning Zhang*. Down-regulation of 3-phosphoinositide -dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. Molecular Cancer Research 2009 Jun;7(6):944-54.(共同通訊作者) IF=4.288

    9,、Jingna Wang, Wuzhou Wan, Ronghua Sun, Ying Liu, Xiangjun Sun, Dalong Ma, Ning Zhang*. Reduction of Akt2 expression inhibits chemotaxis signal transduction in human breast cancer cells. Cellular Signalling 2008 Jun;20(6):1025-34.(通訊作者) IF=4.058

    10,、Ronghua Sun, Ping Gao, Lin Chen, Dalong Ma, Jiming Wang, Joost J. Oppenheim, Ning Zhang*. Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells. Cancer Research. 2005 Feb 15; 65(4):1433-41. (通訊作者) IF=7.856

承擔的科研項目

                                                                                （腫瘤細胞生物學(xué)實驗室）